Lil' Bush cracks satirical jokes at the Bush administration. The show depicts the administration members as pint-size cartoon characters. The title character is accompanied by Lil' Cheney and Lil' Condi.

Cast:
Iggy Pop Iggy Pop
Lil' Rummy (voice) 
Kari Wahlgren Kari Wahlgren
Li'l Condi / Li'l Hillary (voice) 
Dave B. Mitchell Dave B. Mitchell
George Sr. / Jeb Bush / ... (voice) 
Christopher Lee Parson Christopher Lee Parson
Lil' George (voice) 
Donick Cary Donick Cary
Lil' Cheney (voice) 
Ann Villella Ann Villella
Lil' Condi (voice)