As Emily struggles to fit in at home and at school, she discovers a small red puppy who is destined to become her best friend. When Clifford magically undergoes one heck of a growth spurt, becomes a gigantic dog and attracts the attention of a genetics company, Emily and her Uncle Casey have to fight the forces of greed as they go on the run across New York City. Along the way, Clifford affects the lives of everyone around him and teaches Emily and her uncle the true meaning of acceptance and unconditional love.

Directed by: Walt Becker
Written by: Blaise Hemingway & Jay Scherick & David Ronn
Release date: 2021-11-10
Runtime: 97 minutes
Tagline: Adventure has never been bigger.
Cast:
Sienna Guillory Sienna Guillory
Maggie 
John Cleese John Cleese
Mr. Bridwell 
Rosie Perez Rosie Perez
Lucille 
David Alan Grier David Alan Grier
Packard 
Russell Wong Russell Wong
Mr. Yu 
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Also known as:
  • Clifford de grote rode hond
  • Clifford, el gran perro rojo
  • Clifford, o Cão Vermelho
  • Clifford, suur punane koer
  • Sarkanais suns Klifords